Prevalence of Chromosomal Abnormalities in Iranian Patients with Infertility

نویسندگان

چکیده

Background: The numerical and structural abnormalities of chromosomes are the most common cause infertility. Here, we evaluated prevalence types chromosomal in Iranian infertile patients. Methods: We enrolled 1750 couples reproductive age with infertility, who referred to infertility clinics Tehran during 2014- 2019, order perform analysis. Peripheral blood samples were obtained from all by G-banded metaphase karyotyping. In some cases, detected confirmed using fluorescence in-situ hybridization (FISH). Results: various 114/3500 (3.257%) patients was 44/114 (38.596%) among females 70/114 (61.403%) males. Structural found 27/1750 35/1750 Numerical 17/1750 45, XY, rob (13;14) (p10q10) translocation Klinefelter syndrome (47, XXY) patients, respectively. Conclusion: general, a high problems. Our study highlights importance cytogenetic studies before starting treatments approaches.

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ژورنال

عنوان ژورنال: Archives of Iranian Medicine

سال: 2023

ISSN: ['1029-2977', '1735-3947']

DOI: https://doi.org/10.34172/aim.2023.17